Evaluation of laser speckle contrast imaging as an intrinsic method to monitor blood brain barrier integrity | Zendy

Suzie Dufour | Zendy; Yaaseen Atchia | Zendy; Raanan Gad | Zendy; Dene Ringuette | Zendy; Iliya Sigal | Zendy; Ofer Levi | Zendy

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Evaluation of laser speckle contrast imaging as an intrinsic method to monitor blood brain barrier integrity

Author(s) -

Suzie Dufour,

Yaaseen Atchia,

Raanan Gad,

Dene Ringuette,

Iliya Sigal,

Ofer Levi

Publication year - 2013

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.4.001856

Subject(s) - speckle pattern , blood–brain barrier , neuroimaging , speckle imaging , optics , medicine , biomedical engineering , pathology , neuroscience , psychology , central nervous system , physics

The integrity of the blood brain barrier (BBB) can contribute to the development of many brain disorders. We evaluate laser speckle contrast imaging (LSCI) as an intrinsic modality for monitoring BBB disruptions through simultaneous fluorescence and LSCI with vertical cavity surface emitting lasers (VCSELs). We demonstrated that drug-induced BBB opening was associated with a relative change of the arterial and venous blood velocities. Cross-sectional flow velocity ratio (veins/arteries) decreased significantly in rats treated with BBB-opening drugs, ≤0.81 of initial values.

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