Histopathological aspects of breast cancer in relation to some epidemiological risk factors

Case control epidemiological study of 300 breast cancer cases from Dr Cipto Mangunkusumo HospitaL has been performed in 1989-1991. By applying the Japanese Breast Cancer Society classification, the histopathological pafiern ofbreast cancer showed that from the invasive ductal carcinoma type, scirrhous type was found in 147 cases (49Vo), solid-tubular type in 79 cases (26.33Vo) and papilotubular type in 39 cases (I3Vo). According to WHO classification (1951); they were diagnosed as: invasive ductal carcinoma in 265 cases (88.33Vo), invasive lobular carcinoma in 7 cases (2.33Vo), medullary carcinoma in I7 cases (5.68Eo), adenoid cystic carcinoma inI case(0.33Vo),purePaget'sdiseaseof thenipplein2cases(0.67Vo)and4cases(l.33Eo)of thenoninvasivecarcinomawereductal carcinoma in situ. Analysis of the signfficant riskfactors among the Indonesian female breast cancer revealed that the following factors: living at urban area, young sexual activity, trauma, obesity, late menarche, irregular cycle, menopause, fafiy diet and coconut milk containing food consu'mptiolx increased the risk. Relationship of the riskfactors to histopathological types has been stastistically analyzed. The resubs showed that increased possibility to have the invasive ductal carcinoma was related to consumption of coconut milk containing food. The effect was relatecl to the three histological subtypes, namely: papillary tubuLar, solid tubular arul scirrhous types. Coconut milk drinks andfreshvegetables showed decreasing effect, whichwas irrespective to subtypes.