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Synergistic affect of ifampisin and ampicillin has been studi.ed on 20 isolates of S. aureus. Isolates used were ampicillin resistent and rifumpicin sensitive' Susceptibility of the isolate to rifampicin was determined with standard broth dilution method and resistance obsert'ed only in p-lactamase positive isolates. We concluded that there is synergistic effect of rifampicin and ampicilinwhich most likely mediated by inhibition of p-lactamase production by rifumpicin.

medical journal of indonesia

Increased susceptibility of &lt;em&gt;S. aureus&lt;/em&gt; to ampicillin during exposure to rifampicin: A distinct mechanism of antimicrobial synergism