The accuracy of warfarin dosage based on VKORC1 and CYP2C9 phenotypes in a Chinese population | Zendy

Agustinus Fritz Wijaya | Zendy; Jiang T. Bo | Zendy; Jun He | Zendy; Jiang W. Ping | Zendy; Bin Jiang | Zendy; Chen H. Jie | Zendy; Yang Wen | Zendy; Xu Zhu | Zendy; Qiu Q. Cheng | Zendy

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The accuracy of warfarin dosage based on VKORC1 and CYP2C9 phenotypes in a Chinese population

Author(s) -

Agustinus Fritz Wijaya,

Jiang T. Bo,

Jun He,

Jiang W. Ping,

Bin Jiang,

Chen H. Jie,

Yang Wen,

Xu Zhu,

Qiu Q. Cheng

Publication year - 2012

Publication title -

medical journal of indonesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.164

H-Index - 9

eISSN - 2252-8083

pISSN - 0853-1773

DOI - 10.13181/mji.v21i2.489

Subject(s) - vkorc1 , cyp2c9 , warfarin , medicine , pharmacogenetics , genotype , gastroenterology , population , pharmacology , biology , genetics , atrial fibrillation , gene , environmental health , cytochrome p450 , metabolism

Background: The aim of this study is to assess the accuracy of warfarin dosage based on VKORC1 and CYP2C9 genotype in Chinese population. Methods: Blood samples were taken from 37 patients. We compared the warfarin dosage obtained from genotype (according to www.warfarindosing.org) and treatment dosage with international normalized ratio (INR) value within 2.0-3.0. Results: The majority of Chinese people in our study are VKORC1 homozygous AA (89.2%), rarely VKORC1 heterozygous AG and we cannot find a patient with homozygous GG. For CYP2C9 genotype, most patients have the wildtype variants (CYP2C9*2 CC and CYP2C9*3 AA). The warfarin dosage for patients with VKORC1 AA and CYP2C9*3 AC is lower than for patients with other genotype variants. Conclusion: There is no significant difference between pharmacogenetic algorithm (www.warfarindosing.org) and our treatment dosage. Our conclusion is that the pharmacogenetic algorithm is accurate to predict the warfarin dose. (Med J Indones. 2012;21:108-12) Keywords: CYP2C9, pharmacogenetic algorithm, VKORC1, warfarin

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