Open AccessTyrosinase Inhibition Type of Isolated Compounds Obtained from Pachyrhizus erosus
Author(s) -
Endang Lukitaningsih,
Muhammad Bahi,
Ulrike Holzgrabe
Publication year - 2014
Publication title -
aceh international journal of science and technology
Language(s) - English
Resource type - Journals
eISSN - 2503-2348
pISSN - 2088-9860
DOI - 10.13170/aijst.2.3.1063
Subject(s) - daidzin , genistin , chemistry , tyrosinase , skin whitening , daidzein , non competitive inhibition , rutin , antioxidant , traditional medicine , stereochemistry , pharmacology , biochemistry , genistein , enzyme , active ingredient , biology , medicine , endocrinology
- In Indonesia, Bengkoang (Phacyrhizus erosus) have been used as one of cosmetics especially as sun screening and skin whitening materials. Six active compounds in Bengkoang with antioxidant and skin whitening activities have been isolated, namely daidzein, daidzin, genistin, (8,9)-furanyl-pterocarpan-3-ol, 4-(2-(furane-2-yl)ethyl)-2-methyl-2,5-dihydro-furane-3-carbaldehyde and 2-butoxy-2,5-bis(hydroxymethyl)-tetrahydrofurane-3,4-diol. According to literatures, the type of their tyrosinase inhibitory activity has not yet reported. The determination of whitening activity of each compound was evaluated by the evaluation of Lineweaver-Burk plot. The result showed that five compounds had competitive inhibitory activity and 8,9-furanyl-pterocarpan-3-ol showed a non-competitive inhibition.
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