Cytokines in Preterm Delivery | Zendy

Mohammad Kazemi Arababadi | Zendy; Fariba Aminzadeh | Zendy; Gholamhossein Hassanshahi | Zendy; Hossein Khorramdelazad | Zendy; Mojgan Norouzi | Zendy; Ebrahim Rezazadeh Zarandi | Zendy; Mohammad Taghi Rezayati | Zendy; Derek Kennedy | Zendy

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Cytokines in Preterm Delivery

Author(s) -

Mohammad Kazemi Arababadi,

Fariba Aminzadeh,

Gholamhossein Hassanshahi,

Hossein Khorramdelazad,

Mojgan Norouzi,

Ebrahim Rezazadeh Zarandi,

Mohammad Taghi Rezayati,

Derek Kennedy

Publication year - 2012

Publication title -

laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 1943-7730

pISSN - 0007-5027

DOI - 10.1309/lmy9ilpgsetu2co0

Subject(s) - cord blood , medicine , preterm delivery , interleukin 6 , preterm labor , full term , obstetrics , interleukin , pediatrics , cytokine , immunology , pregnancy , gestation , biology , genetics

Background: This study aimed to investigate the serum levels of interleukin-12 (IL-12), interleukin-10 (IL-10), and interleukin-6 (IL-6) in preterm neonates and their mothers and to compare them with those of full-term neonates and their mothers. Materials and Methods: One hundred cord blood specimens from full-term neonates and 60 from preterm neonates were collected. Likewise, 100 plasma samples from the mothers of the full-term neonates and 60 from the mothers of the preterm neonates were collected. Serum levels of IL-12, IL-10, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Results: Cord blood levels of IL-12 and serum levels of IL-6 were higher in preterm neonates and their mothers, respectively. Conclusion: Based on these findings, serum levels of IL-6 and IL-12 may be associated with preterm delivery. More studies must be completed to confirm the key role of these cytokines for the prognosis of preterm labor.No Full Tex

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