Gains at the 1p36 Chromosomal Region Are Associated With Symptomatic Leptomeningeal Dissemination of Supratentorial Glioblastomas | Zendy

Andrey Korshunov | Zendy; Regina Sycheva | Zendy; Andrey Golanov | Zendy; Igor Pronin | Zendy

Open Access

Gains at the 1p36 Chromosomal Region Are Associated With Symptomatic Leptomeningeal Dissemination of Supratentorial Glioblastomas

Author(s) -

Andrey Korshunov,

Regina Sycheva,

Andrey Golanov,

Igor Pronin

Publication year - 2007

Publication title -

american journal of clinical pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.859

H-Index - 128

eISSN - 1943-7722

pISSN - 0002-9173

DOI - 10.1309/de4lnx3ymaccc1er

Subject(s) - comparative genomic hybridization , fluorescence in situ hybridization , glioblastoma , locus (genetics) , biology , pathology , in situ hybridization , cancer research , medicine , genetics , gene , chromosome , gene expression

Symptomatic craniospinal dissemination of glioblastomas is considered rare, and unambiguous pathologic or molecular predictors of tumor leptomeningeal spread remain to be defined. We performed molecular analysis of 8 glioblastomas with symptomatic leptomeningeal dissemination by using fluorescence in situ hybridization and array-based comparative genomic hybridization (array-CGH). The most frequently encountered alteration was gain of the 1p36 locus, which was found in all 8 samples examined. Array-CGH analysis of 3 available samples also disclosed numerous gains at the 1pter-p36.1 locus involving at least 3 DNA clones from this chromosomal region. Consequently, an analysis of 1p copy number status might be kept in mind as an additional tool for further predicting the clinical course of glioblastoma.

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