Common Genomic Aberrations in Basaloid Squamous Cell Carcinoma and Carcinosarcoma of the Esophagus Detected by CGH and Array CGH | Zendy

IngaMarie Schaefer | Zendy; Christina Enders | Zendy; Andreas Polten | Zendy; Florian Haller | Zendy; Andreas Frölich | Zendy; Silke Cameron | Zendy; Philipp Schüler | Zendy; Peter Schweiger | Zendy; Bastian Gunawan | Zendy; A. Beham | Zendy; L. Füzesi | Zendy

Open Access

Common Genomic Aberrations in Basaloid Squamous Cell Carcinoma and Carcinosarcoma of the Esophagus Detected by CGH and Array CGH

Author(s) -

IngaMarie Schaefer,

Christina Enders,

Andreas Polten,

Florian Haller,

Andreas Frölich,

Silke Cameron,

Philipp Schüler,

Peter Schweiger,

Bastian Gunawan,

A. Beham,

L. Füzesi

Publication year - 2011

Publication title -

american journal of clinical pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.859

H-Index - 128

eISSN - 1943-7722

pISSN - 0002-9173

DOI - 10.1309/ajcpz1o7uuuispnr

Subject(s) - carcinosarcoma , comparative genomic hybridization , esophagus , spindle cell carcinoma , pathology , carcinoma , esophageal disease , epidermoid carcinoma , biology , medicine , anatomy , genetics , chromosome , gene

Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common chromosomal gains at 2p25.3-2p12, 7q21.3-7q22.3, and 11q13.2-11q13.4. Chromosomal losses at 13q31qter were observed in both carcinosarcomas. In addition, progression of genomic instability from in situ to invasive carcinosarcoma could be demonstrated by using array CGH. Our observations suggest a common genetic origin of BSCC and carcinosarcoma.

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