Open AccessSignificance of Lymphatic Invasion and Proliferation on Regional Lymph Node Metastasis in Renal Cell Carcinoma
Author(s) -
Yukio Ishikawa,
Shinsuke Aida,
Seiichi Tamai,
Yoshikiyo Akasaka,
Hideko Kiguchi,
Yuri AkishimaFukasawa,
Masamichi Hayakawa,
Shigehiro Soh,
Kinji Ito,
Masayo Kimura-Matsumoto,
Shigeki Ishiguro,
Chiaki Nishimura,
Itaru Kamata,
Reiko Shimokawa,
Toshiharu Ishii
Publication year - 2007
Publication title -
american journal of clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.859
H-Index - 128
eISSN - 1943-7722
pISSN - 0002-9173
DOI - 10.1309/0ft8wtdkrefhhp4p
Subject(s) - lymphatic system , lymphatic vessel , pathology , lymphovascular invasion , renal cell carcinoma , immunohistochemistry , metastasis , lymph node , medicine , cancer
We studied the associations of lymphatic invasion and lymphatic vessel density around tumors with lymph node (LN) status in renal cell carcinoma (RCC) by immunohistochemical analysis using D2-40 antibody as a lymphatic marker. Surgically removed specimens from 76 cases with RCC, including 16 cases with LN metastasis, were used. Lymphatic vessel density around the tumor increased compared with normal kidneys but was not significant by LN status. Tumor size, tumor cell types, patterns of tumor growth, nuclear grade of tumor cells, venous invasion, lymphatic invasion, and primary tumor stage were predictive factors for LN metastasis. Based on multivariate regression analysis, only lymphatic invasion was an independent risk factor for LN metastasis. The immunohistochemical detection of lymphatics was useful for identifying the lymphatic invasion of RCC, and the presence of lymphatic invasion around RCC was an independent predictive factor for LN metastasis.
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