The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats | Zendy

Jung Hee Lee | Zendy; Yun Kyu Lee | Zendy; HyunJong Lee | Zendy; Jae Soo Kim | Zendy

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The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats

Author(s) -

Jung Hee Lee,

Yun Kyu Lee,

HyunJong Lee,

Jae Soo Kim

Publication year - 2021

Publication title -

journal of acupuncture research

Language(s) - English

Resource type - Journals

eISSN - 2586-2898

pISSN - 2586-288X

DOI - 10.13045/jar.2020.00409

Subject(s) - analgesic , saline , hot plate , lidocaine , positive control , anesthesia , medicine , negative control , hot plate test , pharmacology , chemistry , nociception , traditional medicine , receptor , mechanical engineering , engineering

Background: Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100-500 mg/kg) was examined.Methods: Sprague-Dawley (SD) rats ( n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain.Results: All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group ( p p < 0.05).Conclusion: ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain.

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