Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis | Zendy

Kazunori Hamamura | Zendy; Akinobu Nishimura | Zendy; Takahiro Iino | Zendy; Shinya Takigawa | Zendy; Akihiro Sudo | Zendy; Hiroki Yokota | Zendy

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Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis

Author(s) -

Kazunori Hamamura,

Akinobu Nishimura,

Takahiro Iino,

Shinya Takigawa,

Akihiro Sudo,

Hiroki Yokota

Publication year - 2015

Publication title -

bone and joint research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.639

H-Index - 31

ISSN - 2046-3758

DOI - 10.1302/2046-3758.45.2000378

Subject(s) - osteoarthritis , medicine , cartilage , endoplasmic reticulum , cancer research , chemistry , pathology , anatomy , biochemistry , alternative medicine

Salubrinal is a synthetic agent that elevates phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) and alleviates stress to the endoplasmic reticulum. Previously, we reported that in chondrocytes, Salubrinal attenuates expression and activity of matrix metalloproteinase 13 (MMP13) through downregulating nuclear factor kappa B (NFκB) signalling. We herein examine whether Salubrinal prevents the degradation of articular cartilage in a mouse model of osteoarthritis (OA).

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