Open AccessVancomycin iontophoresis of allograft bone
Author(s) -
Mark C. Edmondson,
Robert E. Day,
David Wood
Publication year - 2014
Publication title -
bone and joint research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.639
H-Index - 31
ISSN - 2046-3758
DOI - 10.1302/2046-3758.34.2000223
Subject(s) - vancomycin , iontophoresis , medicine , joint infections , antibiotics , minimum inhibitory concentration , staphylococcus aureus , surgery , biomedical engineering , microbiology and biotechnology , biology , arthroplasty , radiology , bacteria , genetics , periprosthetic
The most concerning infection of allografts and operative procedures is methicillin resistant Staphylococcus aureus (MRSA) and no current iontophoresed antibiotics effectively combat this microbe. It was initially hypothesised that iontophoresis of vancomycin through bone would not be effective due to its large molecular size and lack of charge. The aim of this study was to determine whether this was a viable procedure and to find the optimum conditions for its use.
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