Creatine Monohydrate as a Therapeutic Aid in Muscular Dystrophy | Zendy

Jared P. Pearlman | Zendy; Roger A. Fielding | Zendy

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Creatine Monohydrate as a Therapeutic Aid in Muscular Dystrophy

Author(s) -

Jared P. Pearlman,

Roger A. Fielding

Publication year - 2006

Publication title -

nutrition reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.958

H-Index - 150

eISSN - 1753-4887

pISSN - 0029-6643

DOI - 10.1301/nr.2006.feb.80-88

Subject(s) - creatine , phosphocreatine , muscular dystrophy , medicine , creatine monohydrate , sarcopenia , atrophy , creatine kinase , physical medicine and rehabilitation , physical therapy , endocrinology , energy metabolism , pathology , alternative medicine , placebo

In recent years, dietary supplementation with creatine has been shown to enhance neuromuscular function in several diseases. Recent studies have suggested that creatine can be beneficial in patients with muscular dystrophy and other mitochondrial cytopathies, and may attenuate sarcopenia and facilitate rehabilitation of disuse atrophy. Though the mechanisms are still unknown, creatine has been shown to decrease cytoplasmic Ca2+ levels and increase intramuscular and cerebral phosphocreatine stores, providing potential musculoskeletal and neuroprotective effects.

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