Open AccessIntestinal Bile Acids Can Bind to and Activate the Vitamin D Receptor
Author(s) -
George Wolf
Publication year - 2002
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1301/002966402320387206
Subject(s) - lithocholic acid , bile acid , catabolism , biochemistry , receptor , chemistry , calcitriol receptor , cyp3a , vitamin , biology , cytochrome p450 , metabolism
An increased level of colon lithocholic acid, a potential tumor promoter, accompanies a high‐fat diet. Lithocholic acid can bind to the intestinal vitamin D receptor and thereby induce the cytochrome CYP3A, which detoxifies lithocholic acid by catabolic reactions.