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Various Schiff bases (3a-e) were prepared by condensation reaction of 8hydroxy-5-quinoline carboxaldehyde 1 and diffrent substituted hippuric acids (2a-e). The schiff Bases (3a-e) were then reacted with acetic anhydride in sodium acetate and yielded 4-(8-hydroxy quiolinden-5-yl)-2-substi-tuted phenyl oxazolone. All the oxazolone derivatives were characterized by elemental analysis, spectral studies and antimicrobial activities, One of the oxazolone (4b) was then treated wiht transition metal salts and yield the metal chelates. All the metal chelates of 4b were characterized by metal; ligand (M:L) ratio, magnetic moment, reflectance spectra and anti-microbial activities.

SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF 4(8-HYDROXYQUINOLIDEN-5-YL)-2-(SUBSTITUTED PHENYL) OXAZOL-5-ONE.