The Relationship of Metabolic Parameters with Serum Uric Acid and Percentage of Body Fat in Obese Adolescents

Objective: To evaluate the relationship of metabolic parameters with serum uric acid and percentage of body fat in obese adolescents. Material and Methods: A total 124 adolescents between 10-16 years of age were included in the study. Two groups were created as normal weight (Control, n=40) and obese (n=84). The obese children were also divided into 2 groups according to the presence or absence of Metabolic Syndrome (MS); Obese MS (-) (n=45) and Obese MS (+) (n=39). Bioelectrical impedance analysis was used to measure the percentage of body fat (BF %). results: The values of body mass index- standard deviation score (BMI-SDS), waist circumference (WC), total body fat-standard deviation score (BF% -SDS), systolic and diastolic blood pressure (BP), fasting insulin, HOMA-IR, triglyceride, HDL and uric acid were significantly different as expected (p<0.001), whereas the fasting blood glucose, total cholesterol and LDL values were similar (p=0.41, p=0.70 and p=0.28, respectively). Percentage of total body fat - standard deviation score and uric acid was significantly correlated with body BMI-SDS, waist circumference (WC), systolic and diastolic BP, fasting insulin, HOMA-IR, triglyceride and HDL (p<0.001). In the multiple linear regressions, it was demonstrated that BF%-SDS was significantly related to the systolic BP (p<0.005), WC (p<0.001) and uric acid (p<0.005). conclusion: Total body fat measured via bioelectrical impedance analysis and uric acid had a close relationship with MS components and may be a useful predictive marker for MS diagnosis.