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The effects of Cannabis sativa on the testosterone level and seminal fluid analysis were studied. A total of twenty-four adult male rats were randomly divided into four experimental groups. Group 1 (control) were fed on 5% ethanol. Group 2,3and 4 were fed 20mg of cannabis in 5% ethanol,20mg of cannabis in 5% ethanol +100mg Vitamin C, and 20mg cannabis in 5% ethanol +1ml honey respectively for 21 consecutive days. The result showed a statistically significant decrease in percentage motile sperm and an increase in the percentage dead sperm (p<0.05).The decrease in the sperm count were not statistically significant. Also the changes in Testosterone hormonal levels were not statistically significant. However, those adverse effects caused by cannabis were reversed by the concomitant administration of vitamin C and honey. Also Vitamin C improved the quality of seminal fluid more than Honey.

The effect of Cannabis sativa on testosterone level and seminal fluid analysis of male Wistar rats