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Cardiovascular disease is number one killer disease in the world. The most common etiology is atherosclerosis. LDL and HDL-cholesterol are often associated with atherosclerosis which are affected by diet. Quercetin and curcumin considered have influence d to LDL and HDL. They are antioxidant that protect against LDL oxidation and raised HDL-cholesterol. In this study, we invest about comparison effect of prevention in LDL and HDL level change, after giving quercetin and curcumin. 20 males Rattus novergicus rats in 200-300 grams divided into 4 groups. Group B, C, D were given high-fat diet for 4 weeks, while group A (negative control) was given standard woof. Group B was positive control and no treatment, C was given quercetin, D was given curcumin. The treatment and giving high-fat diet was done simultaneously to detect prevention effect. HDL and LDL-cholesterol evaluated two times, pre and post-treatment. Result showed the increase prevention level of LDL-cholesterol and decrease prevention level of HDL-cholesterol in group C and D significantly. The best prevention effect is quercetin, p=0.000. Furthermore, we showed there was no significant correlation between DLDL and DHDL-cholesterol level. In conclusion, quercetin and curcumin have a good effect in preventing hypercholesterolemia, however quercetin have better effect than curcumin. Keywords: quercetin curcumin, HDL-cholesterol, LDL-cholesterol

Quercetin And Curcumin Prevent Decreasing Of LDL-Cholesterol And Increasing Of HDL-Cholesterol In High Fat Diet Rats