APPLICATION OF KATG::LUX GENE CONSTRUCT FOR CYTOTOXICITY AND GENOTOXICITY MONITORING OF METOPROLOL IN ENVIRONMENT | Zendy

Ewa Szatyłowicz | Zendy; Eliza Hawrylik | Zendy; Marzena Matejczyk | Zendy

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APPLICATION OF KATG::LUX GENE CONSTRUCT FOR CYTOTOXICITY AND GENOTOXICITY MONITORING OF METOPROLOL IN ENVIRONMENT

Author(s) -

Ewa Szatyłowicz,

Eliza Hawrylik,

Marzena Matejczyk

Publication year - 2017

Publication title -

journal of ecological engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.311

H-Index - 19

eISSN - 2392-0629

pISSN - 2081-139X

DOI - 10.12912/23920629/70258

Subject(s) - genotoxicity , cytotoxicity , metoprolol , gene , chemistry , environmental science , environmental chemistry , microbiology and biotechnology , biology , genetics , medicine , toxicity , in vitro , organic chemistry

The aim of the study was the evaluation of usefulness of Escherichia coli K-12 RFM 443 katG::lux for cytotoxicity and genotoxicity monitoring of metoprolol in the environment. Metoprolol is one of the most popular cardiac drug which belongs to the group of β – blockers. The drug was applied at concentrations ranging from 10–1 mg/cm3 to 10–5 mg/cm3. Obtained data indicated the influence of metoprolol on lux gene expression and katG promotor activity in E.coli K-12. The results indicato the possibility of using of Escherichia coli K-12 RFM 443 strain with katG::lux gene construct in the monitoring of cytotoxicity and genotoxicity cardiac drug residues in the environment.

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