An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays | Zendy

Fabiana Manservisi | Zendy; Clara Babot Marquillas | Zendy; Annalisa Buscaroli | Zendy; James Huff | Zendy; Michelina Lauriola | Zendy; Daniele Mandrioli | Zendy; Marco Manservigi | Zendy; Simona Panzacchi | Zendy; Ellen K. Silbergeld | Zendy; Fiorella Belpoggi | Zendy

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An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays

Author(s) -

Fabiana Manservisi,

Clara Babot Marquillas,

Annalisa Buscaroli,

James Huff,

Michelina Lauriola,

Daniele Mandrioli,

Marco Manservigi,

Simona Panzacchi,

Ellen K. Silbergeld,

Fiorella Belpoggi

Publication year - 2016

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp419

Subject(s) - adverse outcome pathway , developmental toxicity , risk assessment , bioassay , environmental health , protocol (science) , toxicology , risk analysis (engineering) , computer science , medicine , biology , computational biology , pathology , computer security , pregnancy , genetics , gestation , alternative medicine

For nearly five decades long-term studies in rodents have been the accepted benchmark for assessing chronic long-term toxic effects, particularly carcinogenicity, of chemicals. The European Food Safety Authority (EFSA) and the World Health Organization (WHO) have pointed out that the current set of internationally utilized test methods capture only some of the potential adverse effects associated with exposures to these agents over the lifetime.

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