In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children | Zendy

Peter J. Wagner | Zendy; HaeRyung Park | Zendy; Zhaoxi Wang | Zendy; Rory Kirchner | Zendy; Yongyue Wei | Zendy; Li Su | Zendy; Kirstie Stanfield | Zendy; Tomás R. Guilarte | Zendy; Robert O. Wright | Zendy; David C. Christiani | Zendy; Quan Lu | Zendy

Open Access

In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children

Author(s) -

Peter J. Wagner,

HaeRyung Park,

Zhaoxi Wang,

Rory Kirchner,

Yongyue Wei,

Li Su,

Kirstie Stanfield,

Tomás R. Guilarte,

Robert O. Wright,

David C. Christiani,

Quan Lu

Publication year - 2016

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp265

Subject(s) - neural stem cell , biology , transcriptome , chromatin immunoprecipitation , gene , gene expression , gene expression profiling , single nucleotide polymorphism , genome wide association study , stem cell , genetics , bioinformatics , promoter , genotype

Lead (Pb) adversely affects neurodevelopment in children. Neural stem cells (NSCs) play an essential role in shaping the developing brain, yet little is known about how Pb perturbs NSC functions and whether such perturbation contributes to impaired neurodevelopment.

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