In Utero Exposure to Benzo[ a ]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice | Zendy

Matthew J. Meier | Zendy; Jason M. O’Brien | Zendy; Marc A. Beal | Zendy; Beverly Allan | Zendy; Carole L. Yauk | Zendy; Francesco Marchetti | Zendy

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In Utero Exposure to Benzo[ a ]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice

Author(s) -

Matthew J. Meier,

Jason M. O’Brien,

Marc A. Beal,

Beverly Allan,

Carole L. Yauk,

Francesco Marchetti

Publication year - 2016

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp211

Subject(s) - biology , offspring , in utero , andrology , sperm , genetics , mutation , mutagen , germline mutation , population , germline mosaicism , somatic cell , germline , mutation frequency , carcinogen , fetus , pregnancy , gene , medicine , environmental health

Mosaicism, the presence of genetically distinct cell populations within an organism, has emerged as an important contributor to disease. Mutational events occurring during embryonic development can cause mosaicism in any tissue, but the influence of environmental factors on levels of mosaicism is unclear.

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