Health Risk Assessment of Dietary Cadmium Intake: Do Current Guidelines Indicate How Much is Safe? | Zendy

Soisungwan Satarug | Zendy; David A. Vesey | Zendy; Glenda C. Gobé | Zendy

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Health Risk Assessment of Dietary Cadmium Intake: Do Current Guidelines Indicate How Much is Safe?

Author(s) -

Soisungwan Satarug,

David A. Vesey,

Glenda C. Gobé

Publication year - 2017

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp108

Subject(s) - creatinine , medicine , urinary system , breast cancer , kidney disease , hazard ratio , physiology , endocrinology , cancer , confidence interval

Cadmium (Cd), a food-chain contaminant, is a significant health hazard. The kidney is one of the primary sites of injury after chronic Cd exposure. Kidney-based risk assessment establishes the urinary Cd threshold at 5.24 μg/g creatinine, and tolerable dietary intake of Cd at 62 μg/day per 70-kg person. However, cohort studies show that dietary Cd intake below a threshold limit and that tolerable levels may increase the risk of death from cancer, cardiovascular disease, and Alzheimer's disease.

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