Relationship between allergic contact dermatitis and electrophilicity. | Zendy

Herbert S. Rosenkranz | Zendy; G Klopman | Zendy; Ying Ping Zhang | Zendy; Cynthia Graham | Zendy; M. H. Karol | Zendy

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Relationship between allergic contact dermatitis and electrophilicity.

Author(s) -

Herbert S. Rosenkranz,

G Klopman,

Ying Ping Zhang,

Cynthia Graham,

M. H. Karol

Publication year - 1999

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.99107129

Subject(s) - electrophile , allergic contact dermatitis , contact dermatitis , chemistry , identification (biology) , allergy , computational biology , medicine , immunology , biology , biochemistry , ecology , catalysis

To evaluate the role of electrophilicity in the induction of allergic contact dermatitis (ACD) in humans, we compared the structure-activity relationship (SAR) model of ACD with those of electrophilic and nonelectrophilic subsets of chemicals in the ACD database. For these analyses, electrophilicity was defined as the potential of a chemical to induce mutations in Salmonella. It was found that electrophilicity accounted for approximately 30-40% of ACD-inducing ability, and the remainder was associated with nonelectrophilic structures. The identification of these moieties opens the possibility for studying their role in ACD.

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