Does Methylphenidate Cause a Cytogenetic Effect in Children with Attention Deficit Hyperactivity Disorder? | Zendy

Susanne Walitza | Zendy; Birgit Werner | Zendy; Marcel Romanos | Zendy; Andreas Warnke | Zendy; Manfred Gerlach | Zendy; Helga Stopper | Zendy

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Does Methylphenidate Cause a Cytogenetic Effect in Children with Attention Deficit Hyperactivity Disorder?

Author(s) -

Susanne Walitza,

Birgit Werner,

Marcel Romanos,

Andreas Warnke,

Manfred Gerlach,

Helga Stopper

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9866

Subject(s) - methylphenidate , medicine , attention deficit hyperactivity disorder , micronucleus test , medical prescription , pediatrics , psychiatry , prospective cohort study , toxicity , pharmacology

Attention deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in children and adolescents (6-12% affected). Treatment with methylphenidate (MPH) in the United States has increased to a current prescription rate of > 5 million per year. However, a 2005 study by El-Zein and co-workers [Cancer Lett 230:284-291] reporting a 3-fold increase in genomic damage in all 12 analyzed children after 3 months of therapy with MPH resulted in much concern about potential carcinogenic effects. Here we provide new information concerning the cytogenetic effect of MPH in children.

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