Genetic predispositions and childhood cancer. | Zendy

KM Shan | Zendy

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Genetic predispositions and childhood cancer.

Author(s) -

KM Shan

Publication year - 1998

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.98106801

Subject(s) - penetrance , genetic predisposition , cancer , neurofibromatosis , childhood cancer , genetics , medicine , biology , bioinformatics , gene , phenotype

This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the issues faced by molecular biologists and genetic epidemiologists in identifying and analyzing at-risk individuals. The problem of incomplete penetrance in cancer susceptibility is presented and potential models are discussed. The article concludes with a number of tentative conclusions from existing data and speculations for future studies.

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