Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expression in Fetal Mouse Prostate Mesenchyme Cells | Zendy

Catherine A. Richter | Zendy; Julia A. Taylor | Zendy; Rachel L. Ruhlen | Zendy; Wade V. Welshons | Zendy; Frederick S. vom Saal | Zendy

Open Access

Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expression in Fetal Mouse Prostate Mesenchyme Cells

Author(s) -

Catherine A. Richter,

Julia A. Taylor,

Rachel L. Ruhlen,

Wade V. Welshons,

Frederick S. vom Saal

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9804

Subject(s) - endocrinology , medicine , mesenchyme , estrogen receptor , prostate , androgen receptor , estrogen , biology , endocrine disruptor , estrogen receptor alpha , androgen , xenoestrogen , estrogen receptor beta , gene expression , endocrine system , prostate cancer , hormone , gene , microbiology and biotechnology , mesenchymal stem cell , biochemistry , cancer , breast cancer

Hormonal alterations during development have lifelong effects on the prostate gland. Endogenous estrogens, including 17beta-estradiol (E(2)), and synthetic estrogenic endocrine disruptors, such as bisphenol A (BPA), have similar effects on prostate development. Increasing exposure to estrogens within the low-dose, physiologic range results in permanent increases in the size and androgen responsiveness of the prostate, whereas exposure within the high-dose, pharmacologic range has the opposite effects.

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