Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls | Zendy

Pamela J. Lein | Zendy; Dongren Yang | Zendy; Adam D. Bachstetter | Zendy; Hugh A. Tilson | Zendy; G. Jean Harry | Zendy; Ronald F. Mervis | Zendy; Prasada Rao S. Kodavanti | Zendy

Open Access

Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls

Author(s) -

Pamela J. Lein,

Dongren Yang,

Adam D. Bachstetter,

Hugh A. Tilson,

G. Jean Harry,

Ronald F. Mervis,

Prasada Rao S. Kodavanti

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9773

Subject(s) - hippocampus , dendritic spine , ontogeny , hippocampal formation , neurogranin , cerebellum , biology , neuroscience , cortex (anatomy) , prefrontal cortex , physiology , endocrinology , medicine , microbiology and biotechnology , cognition , signal transduction , protein kinase c

Perinatal exposure to polychlorinated biphenyls (PCBs) is associated with decreased IQ scores, impaired learning and memory, psychomotor difficulties, and attentional deficits in children. It is postulated that these neuropsychological deficits reflect altered patterns of neuronal connectivity. To test this hypothesis, we examined the effects of developmental PCB exposure on dendritic growth.

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