Atrazine-Induced Aromatase Expression Is SF-1 Dependent: Implications for Endocrine Disruption in Wildlife and Reproductive Cancers in Humans | Zendy

WuQiang Fan | Zendy; Toshihiko Yanase | Zendy; Hidetaka Morinaga | Zendy; Shigeki Gondo | Zendy; Taijiro Okabe | Zendy; Masatoshi Nomura | Zendy; Tomoko Komatsu | Zendy; Ken-ichirou Morohashi | Zendy; Tyrone B. Hayes | Zendy; Ryoichi Takayanagi | Zendy; Hajime Nawata | Zendy

Open Access

Atrazine-Induced Aromatase Expression Is SF-1 Dependent: Implications for Endocrine Disruption in Wildlife and Reproductive Cancers in Humans

Author(s) -

WuQiang Fan,

Toshihiko Yanase,

Hidetaka Morinaga,

Shigeki Gondo,

Taijiro Okabe,

Masatoshi Nomura,

Tomoko Komatsu,

Ken-ichirou Morohashi,

Tyrone B. Hayes,

Ryoichi Takayanagi,

Hajime Nawata

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9758

Subject(s) - atrazine , simazine , aromatase , endocrine disruptor , medicine , chemistry , biology , endocrinology , endocrine system , hormone , pesticide , cancer , breast cancer , agronomy

Atrazine is a potent endocrine disruptor that increases aromatase expression in some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase and subsequent elevation of cAMP.

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