Open AccessA dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens.
Author(s) -
Albert R. Cunningham,
Gilles Klopman,
H S Rosenkranz
Publication year - 1997
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.97105s3665
Subject(s) - phytoestrogens , methoxychlor , lipophilicity , metabolite , xenoestrogen , chemistry , receptor , endocrinology , medicine , biology , pharmacology , biochemistry , estrogen , estrogen receptor , pesticide , cancer , breast cancer , agronomy
Using two independent analyses, it is demonstrated that natural (e.g., estradiol) and some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding to specific receptors and may, in fact, differentiate harmful from beneficial estrogens.
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