Low-Dose Exposure and Immunogenicity of Transgenic Maize Expressing the Escherichia coli Heat-Labile Toxin B Subunit | Zendy

April Jean Beyer | Zendy; Kan Wang | Zendy; Amber N. Umble | Zendy; Jeffrey D. Wolt | Zendy; Joan E. Cunnick | Zendy

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Low-Dose Exposure and Immunogenicity of Transgenic Maize Expressing the Escherichia coli Heat-Labile Toxin B Subunit

Author(s) -

April Jean Beyer,

Kan Wang,

Amber N. Umble,

Jeffrey D. Wolt,

Joan E. Cunnick

Publication year - 2006

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9687

Subject(s) - immunogenicity , immune system , immunogen , antibody , enterotoxigenic escherichia coli , biology , immunoglobulin a , transgene , escherichia coli , toxin , immunoglobulin g , immunology , microbiology and biotechnology , enterotoxin , biochemistry , monoclonal antibody , gene

Transgenic maize, which produces the nontoxic B subunit of the Escherichia coli heat-labile toxin (LT-B) in seed, has proven to be an effective oral immunogen in mice. Currently, there is considerable concern over accidental consumption of transgenic maize expressing LT-B by humans and domestic animals. We have yet to define nonimmunogenic levels of transgenic LT-B when ingested.

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