Prediction of rodent carcinogenicity for 30 chemicals. | Zendy

J. Ashby | Zendy

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Prediction of rodent carcinogenicity for 30 chemicals.

Author(s) -

J. Ashby

Publication year - 1996

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.96104s51101

Subject(s) - carcinogen , rodent , toxicology , carcinogenesis , chronic toxicity , toxicity , chemical compound , chemical toxicity , chemistry , biology , environmental chemistry , water pollutants , cancer , genetics , ecology , organic chemistry

Predictions of carcinogenic activity are made for 30 chemicals currently being assessed for rodent carcinogenicity by the U.S. National Toxicology Program. The predictions are based upon the chemical structure, the anticipated or reported mutagenicity, and the reported sub-chronic toxicity of each chemical. It is predicted that 13 chemicals will be noncarcinogenic to rodents, that 7 will be genotoxic carcinogens, and that 10 may show some evidence of presumed nongenotoxic rodent carcinogenesis.

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