Monte Carlo results for the 3-poly test for animal carcinogenicity experiments. | Zendy

Wei Tan | Zendy; J H Zhang | Zendy

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Monte Carlo results for the 3-poly test for animal carcinogenicity experiments.

Author(s) -

Wei Tan,

J H Zhang

Publication year - 1996

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.96104872

Subject(s) - monte carlo method , carcinogen , robustness (evolution) , toxicology , carcinogenesis , biological system , computer science , chemistry , computational biology , biology , mathematics , statistics , genetics , cancer , gene

By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators with moderate or large effect, but, in some cases, it is less powerful for weak initiators or weak promoters. As expected, the 3-poly test is insensitive to the toxicity of many agents.

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