Cyclooxygenase-2 Induction by Arsenite through the IKKβ/NFκB Pathway Exerts an Antiapoptotic Effect in Mouse Epidermal Cl41 cells | Zendy

Weiming Ouyang | Zendy; Dongyun Zhang | Zendy; Qian Ma | Zendy; Jingxia Li | Zendy; Chuanshu Huang | Zendy

Open Access

Cyclooxygenase-2 Induction by Arsenite through the IKKβ/NFκB Pathway Exerts an Antiapoptotic Effect in Mouse Epidermal Cl41 cells

Author(s) -

Weiming Ouyang,

Dongyun Zhang,

Qian Ma,

Jingxia Li,

Chuanshu Huang

Publication year - 2006

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9588

Subject(s) - transfection , iκb kinase , gene knockdown , arsenite , apoptosis , biology , signal transduction , nf κb , kinase , microbiology and biotechnology , cancer research , cell culture , chemistry , biochemistry , genetics , arsenic , organic chemistry

Arsenic contamination has become a major public health concern worldwide. Epidemiologic data show that long-term arsenic exposure results in the risk of skin cancer. However, the mechanisms underlying carcinogenic effects of arsenite on skin remain to be studied.

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