Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico. | Zendy

María E. Gonsebatt | Zendy; Ana María Salazar | Zendy; Regina Montero | Zendy; Fernando DíazBarriga | Zendy; Leticia Yáñez | Zendy; H. Gómez | Zendy; Patricia OstroskyWegman | Zendy

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Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.

Author(s) -

María E. Gonsebatt,

Ana María Salazar,

Regina Montero,

Fernando DíazBarriga,

Leticia Yáñez,

H. Gómez,

Patricia OstroskyWegman

Publication year - 1995

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.95103s1111

Subject(s) - sister chromatid exchange , hazardous waste , sister chromatids , genotoxicity , occupational exposure , toxicology , mutagen , toxicity , chromosome aberration , environmental health , biology , chemistry , medicine , genetics , carcinogen , chromosome , gene , dna , ecology

Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher frequencies of chromatid and chromosomal deletions, the magnitude of which was related with exposure time. This study suggests that when high-risk exposure is suspected, determining biomarkers of genotoxic damage (e.g., chromosomal aberrations), is useful for risk assessments.

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