Impact of Trivalent Arsenicals on Selenoprotein Synthesis | Zendy

Denis Ganyc | Zendy; Sarah Ryann Talbot | Zendy; Fanta Konate | Zendy; Sarah Jackson | Zendy; Brian Schanen | Zendy; Walter Cullen | Zendy; William T. Self | Zendy

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Impact of Trivalent Arsenicals on Selenoprotein Synthesis

Author(s) -

Denis Ganyc,

Sarah Ryann Talbot,

Fanta Konate,

Sarah Jackson,

Brian Schanen,

Walter Cullen,

William T. Self

Publication year - 2006

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9440

Subject(s) - chemistry , arsenic , selenoprotein p , selenium , selenoprotein , environmental chemistry , biochemistry , glutathione , enzyme , organic chemistry , glutathione peroxidase

Exposure to arsenic has been associated with development of skin, lung, bladder, liver, and kidney cancer. Recent evidence suggests that an increase in oxidative stress in cells treated with arsenicals represents the molecular mechanism behind arsenic-induced carcinogenesis. Selenium, in the form of selenocysteine, is necessary for the activity of several enzymes with a role in defense against reactive oxygen species. A mutual sparing effect between arsenic and selenium has been shown in animal studies when both metalloids are present in high concentrations.

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