New Insight into Intrachromosomal Deletions Induced by Chrysotile in the gpt delta Transgenic Mutation Assay | Zendy

An Xu | Zendy; Lubomir B. Smilenov | Zendy; Peng He | Zendy; Kenichi Masumura | Zendy; Takehiko Nohmi | Zendy; Zengliang Yu | Zendy; Tom K. Hei | Zendy

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New Insight into Intrachromosomal Deletions Induced by Chrysotile in the gpt delta Transgenic Mutation Assay

Author(s) -

An Xu,

Lubomir B. Smilenov,

Peng He,

Kenichi Masumura,

Takehiko Nohmi,

Zengliang Yu,

Tom K. Hei

Publication year - 2006

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9425

Subject(s) - mutant , mutagenesis , chrysotile , microbiology and biotechnology , transgene , mutation , mutagen , dna damage , in vivo , biology , genetically modified mouse , chemistry , dna , genetics , gene , asbestos , materials science , metallurgy

Genotoxicity is often a prerequisite to the development of malignancy. Considerable evidence has shown that exposure to asbestos fibers results in the generation of chromosomal aberrations and multilocus mutations using various in vitro approaches. However, there is less evidence to demonstrate the contribution of deletions to the mutagenicity of asbestos fibers in vivo.

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