A two-stage validation study for determining sensitivity and specificity. | Zendy

Tor D. Tosteson | Zendy; Linda TitusErnstoff | Zendy; John A. Baron | Zendy; Margaret R. Karagas | Zendy

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A two-stage validation study for determining sensitivity and specificity.

Author(s) -

Tor D. Tosteson,

Linda TitusErnstoff,

John A. Baron,

Margaret R. Karagas

Publication year - 1994

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.94102s811

Subject(s) - contingency table , stage (stratigraphy) , statistics , context (archaeology) , estimator , measure (data warehouse) , gold standard (test) , sensitivity (control systems) , mathematics , medicine , computer science , data mining , paleontology , electronic engineering , engineering , biology

A two-stage procedure for estimating sensitivity and specificity is described. The procedure is developed in the context of a validation study for self-reported atypical nevi, a potentially useful measure in the study of risk factors for malignant melanoma. The first stage consists of a sample of N individuals classified only by the test measure. The second stage is a subsample of size m, stratified according the information collected in the first stage, in which the presence of atypical nevi is determined by clinical examination. Using missing data methods for contingency tables, maximum likelihood estimators for the joint distribution of the test measure and the "gold standard" clinical evaluation are presented, along with efficient estimators for the sensitivity and specificity. Asymptotic coefficients of variation are computed to compare alternative sampling strategies for the second stage.

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