Open AccessRespiratory toxicity of copper.
Author(s) -
A. Romeu-Moreno,
Carme Aguilar,
Lluı́s Arola,
Albert Mas
Publication year - 1994
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.94102s3339
Subject(s) - toxicity , copper , metallothionein , chemistry , respiratory system , kidney , lung , toxicokinetics , copper toxicity , absorption (acoustics) , environmental chemistry , biochemistry , chromatography , pharmacology , medicine , biology , materials science , organic chemistry , gene , composite material
Respiratory toxicity of copper was tested in Wistar rats by spraying copper sulfate (330 g/l spray) for daily periods of 1 hr in a self-contained chamber for up to 10 days. The respiratory toxicity was compared with that from intraperitoneal administration of 1 mg Cu/mg body weight and with adequate control rats. Analysis of tissue Cu and Zn was done in lung, liver, kidney, and plasma by using atomic absorption spectrophotometry. Similar organ and subcellular distribution of both elements were found between the two treated groups, and only statistically significant higher levels of Cu were found in plasma and liver. After exposure, Cu and Zn were basically associated with a low-molecular-weight component, which eluted as metallothionein in the postmicrosomal fractions.
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