Open AccessThe cytochromes P450 and mechanisms of chemical carcinogenesis.
Author(s) -
D. V. Parke
Publication year - 1994
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.94102852
Subject(s) - carcinogenesis , reactive oxygen species , glycocalyx , dna damage , chemistry , enzyme , microbiology and biotechnology , biochemistry , carcinogen , biology , cancer research , dna , gene
This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.
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