Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New Biomarkers
Author(s) -
Cornelia Schmutzler,
Inka Gotthardt,
Peter Hofmann,
Branislav Radović,
Gábor L. Kovaćs,
Luise Stemmler,
Inga Nobis,
Anja Bacinski,
Birgit Mentrup,
Petra Ambrugger,
Annette Grüters,
Ludwik K. Malendowicz,
Julie Christoffel,
Hubertus Jarry,
Dana SeidlováWuttke,
W. Wuttke,
Josef Köhrle
Publication year - 2007
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.9369
Subject(s) - thyroid , thyroid hormone receptor , thyroid peroxidase , hormone , medicine , endocrinology , endocrine system , endocrine gland , thyroid hormone receptor beta , hypothalamic–pituitary–thyroid axis , deiodinase , in vivo , triiodothyronine , thyroid stimulating hormone , thyroid function , biology , chemistry , hormone receptor , cancer , breast cancer , microbiology and biotechnology
There is growing evidence that, in addition to the reproductive system, the hypothalamic-pituitary-thyroid axis is a target of endocrine-disrupting compounds (EDCs). However, this is not reflected adequately in current screening and assessment procedures for endocrine activity that to date determine only general parameters of thyroid function.
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