Effects of Chronic Genistein Treatment in Mammary Gland, Uterus, and Vagina | Zendy

Guillermo Rimoldi | Zendy; Julie Christoffel | Zendy; Dana SeidlováWuttke | Zendy; Hubertus Jarry | Zendy; W. Wuttke | Zendy

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Effects of Chronic Genistein Treatment in Mammary Gland, Uterus, and Vagina

Author(s) -

Guillermo Rimoldi,

Julie Christoffel,

Dana SeidlováWuttke,

Hubertus Jarry,

W. Wuttke

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9367

Subject(s) - genistein , uterus , vagina , mammary gland , medicine , physiology , gynecology , biology , endocrinology , anatomy , cancer , breast cancer

The isoflavone genistein (GEN) is found in soy (Glycine max) and red clover (Trifolium pratense). The estrogenic activity of GEN is known, and it is widely advertised as a phytoestrogen useful in alleviating climacteric complaints and other postmenopausal disorders. Knowledge of effects of long-term administration of GEN in laboratory animals is scarce, and effects in the uterus and mammary gland after long-term administration have not been studied. The uterus and mammary gland are known to be negatively influenced by estrogens used in hormone therapy.

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