Tetrahydrofurandiols (THF-diols), Leukotoxindiols (LTX-diols), and Endocrine Disruption in Rats | Zendy

Barry M. Markaverich | Zendy; Mary Ann Alejandro | Zendy; Trellis Thompson | Zendy; Shaila K. Mani | Zendy; Andrea Reyna | Zendy; Wendy Portillo | Zendy; John J. Sharp | Zendy; John Turk | Zendy; Jan R. Crowley | Zendy

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Tetrahydrofurandiols (THF-diols), Leukotoxindiols (LTX-diols), and Endocrine Disruption in Rats

Author(s) -

Barry M. Markaverich,

Mary Ann Alejandro,

Trellis Thompson,

Shaila K. Mani,

Andrea Reyna,

Wendy Portillo,

John J. Sharp,

John Turk,

Jan R. Crowley

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9311

Subject(s) - chemistry , estrous cycle , medicine , diol , metabolism , endocrine system , endocrinology , biochemistry , hormone , organic chemistry , biology

Ground corncob animal bedding and corn food products contain substances that disrupt endocrine function in rats. The disruptors were identified as isomeric mixtures of tetrahydrofurandiols (THF-diols; 9,12-oxy-10,13-dihydroxyoctadecanoic acid and 10,13-oxy-9,12-dihydroxyoctadecanoic acid) and leukotoxindiols (LTX-diols; 9,10-dihydroxy-12-octadecenoic acid and 12,13-dihydroxy-9-octadecenoic acid). The authentic compounds blocked sexual behavior in male rats and estrous cyclicity in female rats at oral doses of 2 ppm.

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