Sensitivity of lymphocytes from vulcanizers to the in vitro induction of sister chromatid exchanges. | Zendy

Francesca Degrassi | Zendy; R. De Salvia | Zendy; Mario Fiore | Zendy; R. Ricordy | Zendy; C. Tanzarella | Zendy; Roberto Benigni | Zendy; F. Palitti | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Sensitivity of lymphocytes from vulcanizers to the in vitro induction of sister chromatid exchanges.

Author(s) -

Francesca Degrassi,

R. De Salvia,

Mario Fiore,

R. Ricordy,

C. Tanzarella,

Roberto Benigni,

F. Palitti

Publication year - 1993

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.93101s397

Subject(s) - sister chromatids , sister chromatid exchange , mitomycin c , in vitro , genetics , biology , chromatid , mutagen , toxicology , immunology , carcinogen , chromosome , gene

Spontaneous frequencies of sister chromatid exchanges (SCEs) and SCEs induced in vitro by chemicals with different mechanisms of action such as mitomycin C, 4-nitroquinoline oxide, and 3-aminobenzamide were examined in phytohemagglutinin-stimulated peripheral blood lymphocytes from a group of workers in a rubber plant and a control group, both of which had been analyzed for levels of spontaneous SCEs 2 years earlier. An interindividual variability in the induction of SCEs was found after in vitro treatments with the different mutagens, which did not correlate with occupational exposure. This variability in the sensitivity to the induction of SCEs might be correlated to genetic differences among individuals, which have to be taken into account in environmental monitoring programs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research