Succimer Chelation Improves Learning, Attention, and Arousal Regulation in Lead-Exposed Rats but Produces Lasting Cognitive Impairment in the Absence of Lead Exposure | Zendy

Diane E. Stangle | Zendy; Donald R. Smith | Zendy; Stéphane A. Beaudin | Zendy; Myla Strawderman | Zendy; David A. Levitsky | Zendy; Barbara J. Strupp | Zendy

Open Access

Succimer Chelation Improves Learning, Attention, and Arousal Regulation in Lead-Exposed Rats but Produces Lasting Cognitive Impairment in the Absence of Lead Exposure

Author(s) -

Diane E. Stangle,

Donald R. Smith,

Stéphane A. Beaudin,

Myla Strawderman,

David A. Levitsky,

Barbara J. Strupp

Publication year - 2006

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9263

Subject(s) - arousal , lead exposure , cognition , affect (linguistics) , chelation therapy , regimen , medicine , lead poisoning , physiology , adverse effect , psychology , pharmacology , neuroscience , psychiatry , cats , communication , thalassemia

There is growing pressure for clinicians to prescribe chelation therapy at only slightly elevated blood lead levels. However, very few studies have evaluated whether chelation improves cognitive outcomes in Pb-exposed children, or whether these agents have adverse effects that may affect brain development in the absence of Pb exposure.

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