Lessons learned from studies on tumor suppression by microcell-mediated chromosome transfer. | Zendy

Mitsuo Oshimura | Zendy

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Lessons learned from studies on tumor suppression by microcell-mediated chromosome transfer.

Author(s) -

Mitsuo Oshimura

Publication year - 1991

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.919357

Subject(s) - medical education , medicine , library science , psychology , computer science

One approach for identifying chromosomes that carry putative tumor-suppressor genes is the introduction of individual, normal human chromosomes to the tumor cells of interest (1-4). In order to identify human chromosomes that can suppress or modulate tumor-associated phentotypes of tumor cells, we performed chromosome transfer experiments via microcell fusion into cell lines derived from a variety of tumors: neuroblastoma (SK-N-MC), fibrosarcoma (HT1080), uterine endometrial carcinoma (HHUA), renal cell carcinoma (YCR), choriocarcinoma (CC1), uterine cervical carci-

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