Open AccessLead exposure and neurobehavioral development in later infancy.
Author(s) -
Kim N. Dietrich,
Paul Succop,
Robert L. Bornschein,
K. M. Krafft,
Omer G. Berger,
P. Brett Hammond,
C. Ralph Buncher
Publication year - 1990
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.908913
Subject(s) - bayley scales of infant development , psychomotor learning , lead exposure , medicine , physiology , prenatal exposure , pediatrics , lead (geology) , prenatal development , prospective cohort study , fetus , blood lead level , lead poisoning , pregnancy , gestation , obstetrics , biology , cognition , psychiatry , cats , paleontology , genetics
A prospective methodology was used to assess the neurobehavioral effects of fetal and postnatal lead exposure during the first 2 years of life. Lead was measured in whole blood prenatally in mothers and at quarterly intervals in the infant. Prenatal blood lead levels were low (mean = 8.0 micrograms/dL). However, approximately 25% of the study infants had at least one serial blood lead level of 25 micrograms/dL or higher during the second year of life. Multiple regression and structural equation analyses revealed statistically significant relationships between prenatal and neonatal blood lead level and 3- and 6-month Bayley Mental and/or Psychomotor Development Index. However, by 2 years of age, no statistically significant effects of prenatal or postnatal lead exposure on neurobehavioral development could be detected. Data consistent with the hypothesis that a postnatal neurobehavioral growth catch-up occurred in infants exposed fetally to higher levels of lead are presented.
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