Studies of the expression of the cytochrome P450IA, P450IIB, and P450IIC gene family in extrahepatic and hepatic tissues. | Zendy

Thomas Friedberg | Zendy; Peter Siegert | Zendy; Markus A. Grassow | Zendy; B Bartłomowicz | Zendy; Franz Oesch | Zendy

Open Access

Studies of the expression of the cytochrome P450IA, P450IIB, and P450IIC gene family in extrahepatic and hepatic tissues.

Author(s) -

Thomas Friedberg,

Peter Siegert,

Markus A. Grassow,

B Bartłomowicz,

Franz Oesch

Publication year - 1990

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.908867

Subject(s) - cytochrome , subfamily , biology , gene , carcinogen , cytochrome p450 , phenobarbital , gene expression , microbiology and biotechnology , methylcholanthrene , gene family , genetics , biochemistry , endocrinology , metabolism , enzyme

We have studied the expression of three P-450 gene subfamilies in hepatic and extrahepatic tissues using the sensitive RNAse A protection assay. Members of the P450IA subfamily, which encodes the major methylcholanthrene-inducible cytochromes P-450, were found to be not expressed in extrahepatic tissues of untreated animals, raising the question whether these P-450 play a role in the metabolism of carcinogens in unexposed individuals. In contrast, members of the P450IIB family, some of which encode the major phenobarbital-inducible cytochromes P-450, were found to be expressed in some extrahepatic tissues of untreated rats and here most notably in the lung and in sebaceous glands. Members of the P450IIC family, which encode some constitutively expressed cytochromes P-450, were found to be expressed exclusively in the liver.

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