Growth control in mammalian cells by cell-cell contacts. | Zendy

Raimund Wieser | Zendy; Doris Renauer | Zendy; A Schäfer | Zendy; Rosario Heck | Zendy; Renate Engel | Zendy; S Schütz | Zendy; Franz Oesch | Zendy

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Growth control in mammalian cells by cell-cell contacts.

Author(s) -

Raimund Wieser,

Doris Renauer,

A Schäfer,

Rosario Heck,

Renate Engel,

S Schütz,

Franz Oesch

Publication year - 1990

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.9088251

Subject(s) - receptor , microbiology and biotechnology , cell growth , cell , cell surface receptor , glycoprotein , cell membrane , contact inhibition , glycan , in vitro , wi 38 , biology , cell function , membrane glycoproteins , chemistry , biochemistry , ploidy , gene

Growth of normal diploid mammalian cells in vitro is strongly regulated by the actual cell density. Cell-cell contacts via specific plasma membrane glycoproteins whose glycan moieties interact with specific receptors has been found to be a main growth regulatory principle. Malignant growth is suggested to result from impaired function of these receptors.

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