Translocation of Inhaled Ultrafine Manganese Oxide Particles to the CentralNervous System
Author(s) -
Alison Elder,
Robert Gelein,
Vanessa Silva,
Tessa Feikert,
Lisa A. Opanashuk,
Janet Carter,
Russell M. Potter,
Andrew Maynard,
Yasuo Ito,
Jacob N. Finkelstein,
Günter Oberdörster
Publication year - 2006
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.9030
Subject(s) - olfactory bulb , nostril , ultrafine particle , olfactory epithelium , chemistry , glial fibrillary acidic protein , olfactory system , central nervous system , pathology , endocrinology , anatomy , biology , biochemistry , medicine , receptor , nose , neuroscience , immunohistochemistry , organic chemistry
Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; <100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel along the olfactory nerve to the olfactory bulb.
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